Tumour Therapy with HIFU

(High Intensity Focused Ultrasound)


Those diseases that medicines do not cure are cured by the knife… Those that the knife does not cure, are cured by FIRE; and those that fire does not cure must be considered incurable…”                                                                                          Hippocrates (Greece - 400 B.C.)


Ultrasound is a form of vibrational wave. It can transmit harmlessly through living tissues, and this makes it possible to use an extracorporeal source of ultrasound for therapeutic purposes. If ultrasound beams are focused and sufficient ultrasonic energy is concentrated within volume while they propagate through tissues, the temperature in the focal region may be raised to levels at which the tumors are cooked, resulting in tissue ablation. This process occurs without any damage to surrounding or overlying tissues, and the tissue ablation technique that employs such beams is known interchangeably as high intensity focused ultrasound (HIFU)

Several mechanisms are directly involved in the tissue damage induced by HIFU;

  • The first is a thermal effect from the conversion of mechanical energy into heat in the targeted tissue, the thermal effect depends on the temperature achieved during Ultrasound Ablation(UA). If the temperature rise is above a threshold of 56℃ and the exposure time is one second, irreversible cell death will be induced through coagulation necrosis. In fact, the temperature at a focal volume may rise rapidly above 80℃ during Ultrasound Ablation(UA).
  • The second is acoustic cavitation, the presence of small gaseous nuclei existing in subcellular organcelles and fluid in tissue are the source of cavitation, which can expand and contract under influence of the acoustic pressure is more than several thousand Pascals, and the temperatures reach several thousand degrees Celsius, resulting in tissue damage.

Damage to tumor vasculature, caused by HIFU, may account for the third mechanism of the targeted tissue necrosis. It can directly cease the blood supply to the tumor through the destruction of the tumor-nourishing vessels, thus causing deprivation of nutrition and oxygen for the tumor cells, indirectly resulting in coagulation necrosis.

The coagulation necrosis induced by HIFU can be considered as the result of biological effects from a combination of heat, cavitation and vascular destruction on tissue.

Advantages of HIFU:

HIFU has none of problems below;                                 HIFU is;
• Risk of infection                                                                 • One time Treatment
• Post operative pain                                                           • Real-time US or MRI guided Procedure
• Hospital stay                                                                     • 3D-Conformal Treatment
• Recovery time                                                                   • Anti-tumor immunity activated
• Disfiguring                                                                         • Minor complications
• Loss of earnings                                                                • Day Care basis
                                                                                             • Low overall cost
                                                                                             • Enhancement of quality of life


Clinical Indications:

Cancers of Pathologies;                                                   Benign Tumours;
• Liver                                                                                   • Uterine Fibroids
• Kidney                                                                                • Uterine adenomyosis 
• Breast                                                                                 • Breast Fibroadenoma
• Pancreas
• Bone
• Soft Tissue
• Metastatic cancers

Never need High Safety Precautions
- No Radiation, No High Construction Costs
- No High-Level Disinfection or  Sterilization
- Treatment in Day-Lighted, Safe, Environmental Facility
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